Our data confirms that DMD children are on average shorter than the UK reference population at age 5 years, by 0.86 (95% CI 0.77, 0.96) SD. Height in DMD boys has been reported to be normal at birth, with a progressive slowdown in growth in the first years of life, but the underlying biological mechanism is still unknown [25]. In particular, skeletal disproportion has been noted [30]. Irrespective of the GC type, daily regimes showed the highest yearly stunting of height. As shown in previous studies [18, 27, 28, 31] participants on daily deflazacort had the greatest stunting of height, showing a loss of 0.25 (95% CI 0.21, 0.3) SD every year compared to the UK 90. However, unlike weight, GC start age was not significantly associated with yearly height change.
Illingworth Normal Child.pdf
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